The 42nd Annual Workshop of the AAPR provides a platform for presentation and discussion of research progress as well as current projects within the AAPR community. In this year’s edition of the workshop, OAGM2018, we additionally focus on the theme of medical image analysis and applications of computer vision, image processing and pattern recognition in the medical context, with the aim to bring together Austrian and nearby located groups working on this topic for discussion and establishing potential collaborations. After a careful review process, finally 19 full papers and 8 featured presentations were considered for the final program. In addition, two invited speakers, Prof. Marleen de Bruijne (Rotterdam/Copenhagen) and Prof. Bjoern Menze (Munich), completed the program by their keynote presentations.